台灣的Duolink (in situ PLA)參考文獻 時間: 2011-01-13 10:36:26
台灣之光!!!
請參考如下:
第一篇
Ann Surg Oncol
DOI 10.1245/s10434-010-0927-1
Clinical Implication and Mitotic Effect of CD44 Cleavage
in Relation to Osteopontin/CD44 Interaction and Dysregulated
Cell Cycle Protein in Gastrointestinal Stromal Tumor

第二篇
Ann Surg Oncol
DOI 10.1245/s10434-010-1143-8
Osteopontin Expression is an Independent Adverse Prognostic
Factor in Resectable Gastrointestinal Stromal Tumor and its
Interaction with CD44 Promotes Tumor Proliferation

以上發表期刊來自"成大臨研所"使用PLA技術探討研究主題!

第三篇
J Biol Chem. 2010 Jun 17. [Epub ahead of print]
PMID: 20558745 [PubMed - as supplied by publisher]

Secreted heat shock protein 90{alpha} induces colorectal cancer cell invasion through CD91/LRP-1 and NF-{kappa}B-mediated integrin {alpha}V expression.
Chen JS, Hsu YM, Chen CC, Chen LL, Lee CC, Huang TS.

第四篇:
J Biol Chem. 2010 Jul 2. [Epub ahead of print]

Heat shock protein 72 is associated with the hepatitis C virus replicase complex and enhances viral RNA replication.
Chen YJ, Chen YH, Chow LP, Tsai YH, Chen PH, Huang CY, Chen WT, Hwang LH.

Institute of Microbiology and Immunology, National Yang-Ming University, Taiwan;

Abstract
The NS5A protein of the hepatitis C virus (HCV) is an integral component of the viral replicase. It also modulates cellular signaling and perturbs host interferon responses. The multifunctional characteristics of NS5A are mostly attributed to its ability to interact with various cellular proteins. This study aimed to identify the novel cellular factors that interact with NS5A and decipher the significance of this interaction in viral replication. The NS5A-interacting proteins were purified by the tandem affinity purification (TAP) procedure from cells expressing NS5A and identified by mass spectrometry. The chaperone protein Hsp72 was identified herein. In vivo protein-protein interaction was verified by co-immunoprecipitation and an in situ proximity ligation assay. In addition to NS5A, Hsp72 was also associated with other members of the replicase complex, NS3 and NS5B, suggesting that it might be directly involved in the HCV replication complex. Hsp72 plays a positive regulatory role in HCV RNA replication by increasing levels of the replicase complex, which was attributed either to the increased stability of the viral proteins in the replicase complex or to the enhanced translational activity of the internal ribosome entry site of HCV. The fact that the host chaperone protein Hsp72 is involved in HCV RNA replication may represent a therapeutic target for controlling virus production.

PMID: 20601427 [PubMed - as supplied by publisher]

第五篇:
Blood. 2010 Nov 1.
Chuang YT, Lin YC, Lin KH, Chou TF, Kuo WC, Yang KT, Wu PR, Chen RH, Kimchi A, Lai MZ.
Tumor suppressor death-associated protein kinase is required for full IL-1{beta} production.
發表作者為中研院分生所 莊雅婷(賴明宗老師實驗室)